CD137 helps regulate the activation of many immune cells, including CD4(+) T cells, CD8(+) T cells, dendritic cells, and natural killer cells. Recent studies indicate that the antitumor efficacy of therapeutic tumor-targeting antibodies can be augmented by the addition of agonistic antibodies targeting CD137.

Administration of low-dose combination anti-CTLA4, anti-CD137, and Distribution studies confirmed expected concentration of antibodies in tumor and tDLN,

CD137 Antibody (0.N.185) is a mouse monoclonal IgG 1 (kappa light chain) provided at 200 µg/ml; raised against recombinant CD137 ectodomain of human origin; recommended for detection of CD137 of human origin by WB, IP, IF and FCM 4‑1BB/TNFRSF9/CD137 in Human Tonsil. 4-1BB/TNFRSF9/CD137 was detected in immersion fixed paraffin-embedded sections of human tonsil using Goat Anti-Human 4-1BB/TNFRSF9/CD137 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF838) at 10 µg/mL overnight at 4 °C. By reconstitution with CD137-deficient Tms, we demonstrate that expression of CD137 on antigen-specific Tms is only partially required for the effect of anti-CD137 antibody. Other host cells, including those from hematopoietic and nonhematopoietic origins, are also important because ablation of CD137 from these cells partially but significantly eliminates antitumor effect of anti-CD137 antibody. Rat Monoclonal CD137 antibody for FACS, WB. Order anti-CD137 antibody ABIN1169067.

Cited in 2 publication(s). Independently reviewed in 1 review(s). Immunogen corresponding to fusion protein. Urelumab (BMS-663513 or anti-4-1BB antibody) is a fully human IgG4 monoclonal antibody developed by Bristol-Myers Squibb for the treatment of cancer and solid tumors.. Urelumab targets the extracellular domain of CD137. It specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. 2020-08-01 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (ab203391) Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue, labeling CD137 using ab203391 at a 1/600 dilution, followed by conjugation to the secondary antibody … APC anti-human CD137 (4-1BB) Antibody - CDw137 is a 39 kD transmembrane protein also known as 4-1BB.

CD137 is a reported synonym of the human protein 'TNF receptor superfamily member 23 Jun 2020 Our experiments in mice suggest that agonistic anti-CD137 mAbs used in cancer and autoimmunity therapy may impair long-term antibody and B cell mem- ory responses.

Immunomodulating antibodies intreatmentmetastatic melanoma:experienceanti-ctla-4, anti-cd137,anti-pd1. Men även faktorer som stress och stort alkoholintag

It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor . 15 Jul 2015 Abstract.

Human 4-1BB/TNFRSF9/CD137 Antibody Stimulates IL-2 Secretion in Human T Cells. Rabbit Anti-Human 4-1BB/TNFRSF9/CD137 Monoclonal Antibody (Catalog # MAB8382) co-stimulates IL-2 secretion in human T cells in the presence of anti-CD3 in a dose-dependent manner, as measured by the Human IL-2 Quantikine ELISA Kit (Catalog # D2050).

Recent studies indicate CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes. Targeting CD137 or its ligand (CD137L) has been studied, aiming to enhance anticancer immune responses. Urelumab (BMS-663513 or anti-4-1BB antibody) is a fully human IgG4 monoclonal antibody developed by Bristol-Myers Squibb for the treatment of cancer and solid tumors. Urelumab targets the extracellular domain of CD137.

APC anti-human CD137 (4-1BB) Antibody - CDw137 is a 39 kD transmembrane protein also known as 4-1BB. CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation. Product Details Rabbit polyclonal CD137 antibody. Validated in IHC and tested in Human.
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It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor .

Utomilumab (PF-05082566) targets this receptor to stimulate a more intense immune system attack on cancers. It is a fully human IgG2 monoclonal antibody. It is in early clinical trials. As of June 2016 5 clinical trials are active.
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CD137 helps regulate the activation of many immune cells, including CD4(+) T cells, CD8(+) T cells, dendritic cells, and natural killer cells. Recent studies indicate that the antitumor efficacy of therapeutic tumor-targeting antibodies c

Product Details 2019-10-02 Anti-CD137 Rabbit Polyclonal Antibody (10041-RP01), manufactured by Sino Biological is validated in ELISA. Custom antibody services and bulk production also available. To learn more comprehensive our antibody product information including immunogen, specificity, and more, you can read all details here.

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Biotin anti-human CD137 (4-1BB) Antibody - CDw137 is a 39 kD transmembrane protein also known as 4-1BB.

Recent insights into the function of TNFR agonist antibodies implicate epitope, affinity, and IgG subclass as critical features, and these observations help explain the limited activity and … This antibody recognizes the CD137 (4-1BB) antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily.